Centriole Engagement: It’s Not Just Cohesin Any More
نویسنده
چکیده
The belief that cohesin complexes link mother to daughter centrioles has received substantial experimental support. New studies challenge the primacy of cohesin in centriole engagement and provide a more nuanced view into the mechanisms for centriole disengagement in anaphase.
منابع مشابه
The linking of plate tectonics and evolutionary divergence
Whereas cohesin cleavage alone did not produce any detectable effects on engaged centrioles, Cdk inhibition, in contrast, was sufficient to induce centriole disengagement even in the absence of proper chromosome disjunction. Upon p27 injection, centriole disengagement was observed with a similar kinetics to the disengagement observed in the TEV+p27 experiments (Figure 1). Our previous experimen...
متن کاملCentrosomal Aki1 and cohesin function in separase-regulated centriole disengagement
Sister chromatid separation at anaphase is triggered by cleavage of the cohesin subunit Scc1, which is mediated by separase. Centriole disengagement also requires separase. This dual role of separase permits concurrent control of these events for accurate metaphase to anaphase transition. Although the molecular mechanism underlying sister chromatid cohesion has been clarified, that of centriole...
متن کاملCohesin: It’s Functions and Relevance to Cancer
Oncogene mutations, inactivation of tumor suppressor genes and chromosome instability are classic features of cancer. The sister chromatid cohesion complex, known as cohesin, is conserved among eukaryotes and is essential for efficient chromosome segregation. In this review, we focus on the key findings about cohesin biology and how cohesin misregulation can be deleterious. Citation: Bhardwaj S...
متن کاملCDK5RAP2 regulates centriole engagement and cohesion in mice.
Centriole duplication occurs once per cell cycle, ensuring that each cell contains two centrosomes, each containing a mother-daughter pair of tightly engaged centrioles at mitotic entry. Loss of the tight engagement between mother and daughter centrioles appears to license the next round of centriole duplication. However, the molecular mechanisms regulating this process remain largely unknown. ...
متن کاملMeiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis.
In many species where oocytes lack centrosomes, sperm contribute both genetic material and centriole(s) to the zygote. Correct centriole organization during male meiosis is critical to guarantee a normal bipolar mitotic spindle in the zygote. During Caenorhabditis elegans male meiosis, centrioles normally undergo two rounds of duplication, resulting in haploid sperm each containing a single tig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 23 شماره
صفحات -
تاریخ انتشار 2013